Conceptual model identifies factors to mitigate risk for opioid misuse during cancer care


Predisposing risk factors identified in four overlapping domains

  • Historical and malleable factors: Depression, anxiety, posttraumatic stress disorder, and other psychological diagnoses; intolerance of distress
  • Current and malleable factors: Chronic pain, psychological diagnoses, deficit in coping skills, opioid availability
  • Historical and unmalleable factors: Family history of substance use disorder, including alcohol use disorder; personal history of substance use disorder; history of sexual victimization; childhood abuse
  • Current and unmalleable factor: Age 16 to 45

Implications for clinical practice: Universal screening, patient education, and mental health care

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